Control of canine renin release: macula densa requires prostaglandin synthesis.
نویسندگان
چکیده
منابع مشابه
Role of the macula densa in renin release.
To examine the role of the macula densa in renin release, afferent arterioles alone or afferent arterioles with the macula densa attached were microdissected from rabbit kidney and incubated in Medium 199 for two consecutive 30-minute periods. Renin concentration in the medium was measured using partially purified rabbit angiotensinogen. Renin release rate over 1 hour from a single arteriole (o...
متن کاملMacula densa sensing and signaling mechanisms of renin release.
Macula densa cells in the distal nephron, according to the classic paradigm, are salt sensors that generate paracrine chemical signals in the juxtaglomerular apparatus to control vital kidney functions, including renal blood flow, glomerular filtration, and renin release. Renin is the rate-limiting step in the activation of the renin-angiotensin system, a key modulator of body fluid homeostasis...
متن کاملRole of macula densa in diuretics-induced renin release.
Diuretic therapy may enhance renin release by various mechanisms, principally contraction of extracellular fluid volume and its effects, including a fall in arterial pressure. Awake hydropenic or volume-expanded rats received diuretics (amiloride and hydrochlorothiazide) that are known inhibitors of NaCl transport beyond the macula densa; also the well-known Na(+)-K(+)-2 Cl- transport system in...
متن کاملIntracellular sodium in macula densa cells and renin release.
It is well established that two microanatomical areas of the kidney (macula densa and juxtaglomerular cells) are in some way associated with the secretion of renin. However, their precise role in the regulation of this hormone remains unresolved. Controversy still exists as to whether the rate of renin secretion is controlled solely by a pressure and stretch sensitive receptor in the juxtaglome...
متن کاملPossible role of adenosine in the macula densa mechanism of renin release in rabbits.
This study was designed to examine: (a) the effects of adenosine and its analogues on renin release in the absence of tubules, glomeruli, and macula densa, and (b) whether adenosine may be involved in a macula densa-mediated renin release mechanism. Rabbit afferent arterioles (Af) alone and afferent arterioles with macula densa attached (Af + MD) were microdissected and incubated for two consec...
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ژورنال
عنوان ژورنال: The Journal of Physiology
سال: 1981
ISSN: 0022-3751
DOI: 10.1113/jphysiol.1981.sp013918